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The season premiere episode features TV personality/actress/singer Kelly Osbourne, playing for the Sharon Osbourne Colon Cancer Program at Cedars-Sinai vs. singer/songwriter/actress JoJo, playing for The Hole in the Wall Gang; and former NFL star/Super Bowl champ/actor Vernon Davis, playing for the Vernon Davis Foundation vs. former NFL star/Super Bowl champ Victor Cruz, playing for the Victor Cruz Foundation.